• Lifestyle
    • All
    • Fashion
    • Food
    • Health
    Yellow Merino Wool Socks

    The Color Psychology of Yellow Merino Wool Socks

    Gold Rope Chains

    Are Gold Rope Chains Still Popular?

    Skateboarding Improve Child's Balance

    How Can Skateboarding Improve Child’s Balance And Coordination?

    Girls Fashion

    Exclusive Girls Fashion

    Hair loss

    Alopecia Areata: Types and Treatments

    Magnesium

    What are the effects of Magnesium?

    Points to Keep in Mind while Going Grocery Shopping

    Hazards of Confined Space

    Hazards of Confined Space

    Create an Awesome T-Shirt

    How to Create an Awesome T-Shirt

  • Business
    Vehicle Expenses

    5 Ways to Reduce Your Vehicle Expenses

    Grow Your Online Business

    7 Strategies to Grow Your Online Business

    Negotiating

    How to Get the Best Deal Negotiating for a Used Truck?

    LMS

    Features for Customer Training in LMS

    Message Broker

    Message Broker Platforms for Developers

    ORM service

    What are the strategies implemented in an ORM service?

    Loans for Small and Medium-Sized Enterprises

    Loans for Small and Medium-Sized Enterprises in Singapore

    Career Advice

    Career Advice: 7 Important Signs That You are in the Right Job

    restaurant paging system

    Top reasons to consider using a restaurant paging system

  • Entertainment
    • All
    • Games
    Activision

    Activision Success Story

    Indigo Prophecy Remastered

    Indigo Prophecy Remastered is a mystery game.

    How to get to Tsurumi Island in Genshin Impact Map?

    How do You Get to Tsurumi Island?

    audio equipment

    Why should you rent audio equipment in London?

    What Are Custom Essay Writing Services?

    How to Watch Formula One Live – Watch Formula One Live TV

    Anne with an E

    Best Comedy-Drama Series Similar To Anne With An E Season 4

  • Celebrity
    Nate Bargatze Is a Great, Fidgety Host for the Tennessee Kid

    Nate Bargatze Is a Great, Fidgety Host for the Tennessee Kid

    Georges Seurat’s Mysterious Death

    Georges Seurat’s Mysterious Death

    mercedes moore

    Mercedes Moore – {Bio, Age, Instagram, Spouse, Networth}

  • Digital Marketing
    • All
    • Social Media
    SEO Best Practices

    SEO Best Practices: How to Update Old Content and Keep Your Rankings Up

    instagram followers

    Now Is The Time For You To Know The Benefits About Instragram Followers Free

    Create Engaging TikTok Videos

    How To Create Engaging TikTok Videos?

    Photoshop

    5 Great Websites To Learn Photoshop Skills & Earn

    blogs

    How To Build Traffic To Your Blogs: A Beginners Guide to Getting More Visitors

    affiliate programs

    Why affiliate programs are advantageous to Your Business.

  • Technology
    Screen Recorder

    How to Choose The Right Screen Recorder For Your Needs

    Soil Moisture Sensors

    Ultimate Guide to Using Soil Moisture Sensors

    Moto Metal Wheels

    4 Reasons Why (Almost) Everyone Adores Moto Metal Wheels!

    8 Tips for a Successful Social Media Video Marketing Strategy

    8 Tips for a Successful Social Media Video Marketing Strategy

    Windows Update Proxy

    How to Configure Windows Update Proxy Settings

    Free Photo Backup

    Cloud Storage Method for Free Photo Backup (Up To 1tb)

    PDF files

    5 Online Tools To Use For Merging Two Or More PDF Files Without Incurring Any Fee

    Android App Development Trends

    5 Best Android App Development Techniques 2022

    Spare Parts For Your Apple Device

    How To Get High-Quality Spare Parts For Your Apple Device?

  • Travel
    Luxurious Hotel In Jaipur

    Enjoy Exceptional Services In The Luxurious Hotel In Jaipur

    Coorg-A paradise

    Coorg-A paradise for tourists to rejuvenate their minds

    Spain train

    Spain train tickets all you need to know

    trip to Disneyland

    How to enjoy a perfect trip to Disneyland?

    Trip To Pune

    What Makes The Trip To Pune Great Excitement For The Tourists?

    Umrah Package

    Why the 5 star Umrah Package in 2022 is the Perfect Gift for Ramadan

    road trip

    Road Trip To Take From Delhi On A Weekend

    andaman honeymoon package

    Have a look at your beautifully planned 7 days Andaman honeymoon package

    Airbag Deactivation

    Airbag Deactivation – When is It Suitable?

  • Crypto
    Cryptocurrency Pricing

    Cryptocurrency Pricing and Options: What to Look Out For.

    Blogging Project

    How To Use Bitcoins To Finance Your Blogging Project.

    Support Your Colleagues At Work

    How to Start and Run an Online Business with Cryptocurrencies.

    Peer-to-Peer Currency

    The Best Thing about Bitcoin is that it’s a Peer-to-Peer Currency.

    Cryptocurrency

    How Cryptocurrencies Are Impacting People’s Lifestyles.

    Cryptocurrencies

    How Cryptocurrencies Impact Scientific Research.

    Bitcoin With SMSF

    How Does Bitcoin Affect the American Economy?

    Cryptocurrency Versus Stock

    Establishing Key Differences Between Investing in Stock Versus Cryptocurrency

    Bitcoin With SMSF

    Your Guide to Buying and Investing in Bitcoin With SMSF

No Result
View All Result
Hub Blogging
  • Lifestyle
    • All
    • Fashion
    • Food
    • Health
    Yellow Merino Wool Socks

    The Color Psychology of Yellow Merino Wool Socks

    Gold Rope Chains

    Are Gold Rope Chains Still Popular?

    Skateboarding Improve Child's Balance

    How Can Skateboarding Improve Child’s Balance And Coordination?

    Girls Fashion

    Exclusive Girls Fashion

    Hair loss

    Alopecia Areata: Types and Treatments

    Magnesium

    What are the effects of Magnesium?

    Points to Keep in Mind while Going Grocery Shopping

    Hazards of Confined Space

    Hazards of Confined Space

    Create an Awesome T-Shirt

    How to Create an Awesome T-Shirt

  • Business
    Vehicle Expenses

    5 Ways to Reduce Your Vehicle Expenses

    Grow Your Online Business

    7 Strategies to Grow Your Online Business

    Negotiating

    How to Get the Best Deal Negotiating for a Used Truck?

    LMS

    Features for Customer Training in LMS

    Message Broker

    Message Broker Platforms for Developers

    ORM service

    What are the strategies implemented in an ORM service?

    Loans for Small and Medium-Sized Enterprises

    Loans for Small and Medium-Sized Enterprises in Singapore

    Career Advice

    Career Advice: 7 Important Signs That You are in the Right Job

    restaurant paging system

    Top reasons to consider using a restaurant paging system

  • Entertainment
    • All
    • Games
    Activision

    Activision Success Story

    Indigo Prophecy Remastered

    Indigo Prophecy Remastered is a mystery game.

    How to get to Tsurumi Island in Genshin Impact Map?

    How do You Get to Tsurumi Island?

    audio equipment

    Why should you rent audio equipment in London?

    What Are Custom Essay Writing Services?

    How to Watch Formula One Live – Watch Formula One Live TV

    Anne with an E

    Best Comedy-Drama Series Similar To Anne With An E Season 4

  • Celebrity
    Nate Bargatze Is a Great, Fidgety Host for the Tennessee Kid

    Nate Bargatze Is a Great, Fidgety Host for the Tennessee Kid

    Georges Seurat’s Mysterious Death

    Georges Seurat’s Mysterious Death

    mercedes moore

    Mercedes Moore – {Bio, Age, Instagram, Spouse, Networth}

  • Digital Marketing
    • All
    • Social Media
    SEO Best Practices

    SEO Best Practices: How to Update Old Content and Keep Your Rankings Up

    instagram followers

    Now Is The Time For You To Know The Benefits About Instragram Followers Free

    Create Engaging TikTok Videos

    How To Create Engaging TikTok Videos?

    Photoshop

    5 Great Websites To Learn Photoshop Skills & Earn

    blogs

    How To Build Traffic To Your Blogs: A Beginners Guide to Getting More Visitors

    affiliate programs

    Why affiliate programs are advantageous to Your Business.

  • Technology
    Screen Recorder

    How to Choose The Right Screen Recorder For Your Needs

    Soil Moisture Sensors

    Ultimate Guide to Using Soil Moisture Sensors

    Moto Metal Wheels

    4 Reasons Why (Almost) Everyone Adores Moto Metal Wheels!

    8 Tips for a Successful Social Media Video Marketing Strategy

    8 Tips for a Successful Social Media Video Marketing Strategy

    Windows Update Proxy

    How to Configure Windows Update Proxy Settings

    Free Photo Backup

    Cloud Storage Method for Free Photo Backup (Up To 1tb)

    PDF files

    5 Online Tools To Use For Merging Two Or More PDF Files Without Incurring Any Fee

    Android App Development Trends

    5 Best Android App Development Techniques 2022

    Spare Parts For Your Apple Device

    How To Get High-Quality Spare Parts For Your Apple Device?

  • Travel
    Luxurious Hotel In Jaipur

    Enjoy Exceptional Services In The Luxurious Hotel In Jaipur

    Coorg-A paradise

    Coorg-A paradise for tourists to rejuvenate their minds

    Spain train

    Spain train tickets all you need to know

    trip to Disneyland

    How to enjoy a perfect trip to Disneyland?

    Trip To Pune

    What Makes The Trip To Pune Great Excitement For The Tourists?

    Umrah Package

    Why the 5 star Umrah Package in 2022 is the Perfect Gift for Ramadan

    road trip

    Road Trip To Take From Delhi On A Weekend

    andaman honeymoon package

    Have a look at your beautifully planned 7 days Andaman honeymoon package

    Airbag Deactivation

    Airbag Deactivation – When is It Suitable?

  • Crypto
    Cryptocurrency Pricing

    Cryptocurrency Pricing and Options: What to Look Out For.

    Blogging Project

    How To Use Bitcoins To Finance Your Blogging Project.

    Support Your Colleagues At Work

    How to Start and Run an Online Business with Cryptocurrencies.

    Peer-to-Peer Currency

    The Best Thing about Bitcoin is that it’s a Peer-to-Peer Currency.

    Cryptocurrency

    How Cryptocurrencies Are Impacting People’s Lifestyles.

    Cryptocurrencies

    How Cryptocurrencies Impact Scientific Research.

    Bitcoin With SMSF

    How Does Bitcoin Affect the American Economy?

    Cryptocurrency Versus Stock

    Establishing Key Differences Between Investing in Stock Versus Cryptocurrency

    Bitcoin With SMSF

    Your Guide to Buying and Investing in Bitcoin With SMSF

No Result
View All Result
Hub Blogging
No Result
View All Result

Modafinil as a Treatment for Sleep Disorders

April 7, 2022
Modalert
 
Modafinil is a psychostimulant that helps you stay awake. It’s used to treat narcolepsy, obstructive sleep apnea, and hypopnea syndrome (when combined with continuous positive airway pressure). As well as chronic shift work sleep disorder when other treatments have failed. Peak blood concentrations and exposure (area under the curve) are larger for modafinil following oral administration than for modafinil at the same dosage. As a result, modafinil is not bioequivalent to modafinil and cannot replaced directly.
 
For narcolepsy and obstructive sleep apnea, modafinil should used once a day in the morning, and one hour before commencing work for people with shift work sleep disorder. In persons with significant hepatic impairment, the dose of modafinil should lowered as well. 
 

Narcolepsy and EDS

 
Narcolepsy affects 0.02 percent to 0.05 percent of the US population, with 5% of sleep-centre patients suffering from the condition. EDS, cataplexy, sleep paralysis, and hypnagogic hallucinations are the four classic symptoms of narcolepsy. The clinical presentations of the erosion of the boundaries between the stages of waking, rapid–eye–movement (REM) sleep, and non–REM sleep are all four of these symptoms. The prevalence of a given gene type is higher in narcolepsy patients than in the general population. 
 
The presence of this subtype, however, is not required nor specific for the diagnosis of narcolepsy. Some researchers now believe narcolepsy caused by an autoimmune condition or induced by an unidentified environmental exposure or event. The finding of hypocretin/orexin, which could be the neurotransmitter predominantly implicated in the development of narcolepsy, is an exciting recent discovery. Narcolepsy thought to caused by a lack of hypocretin in animal models. The findings of the animal investigation validated in a preliminary human study.
 
In terms of practicality, EDS is arguably the most difficult issue for many narcoleptics. Uncontrollable sleepiness creates academic, career, financial, and emotional problems, as well as having a negative impact on one’s quality of life. Treatment of EDS that is effective, safe, and comfortable is a top priority in narcolepsy.
 
It’s no surprise, therefore, that modafinil is now the first-line therapy for EDS in the most recent (2000) version of the American Academy of Sleep Medicine’s narcolepsy practice standards, despite its relatively recent inception.
 
Modalert (Modafinil) effectiveness investigated in two big US studies that were placebo-controlled, double-blinded, randomized, and used parallel groups. For 9 weeks, 554 individuals given either 200 mg or 400 mg of modafinil or placebo in 39 sleep clinics. Modafinil improved wakefulness by 50% to 75%, according to three standardized, validated sleepiness tests: the Multiple Sleep-Latency Test (MSLT), which accurately measures the time necessary to fall asleep; the Maintenance of Wakefulness Test (MWT), which objectively measures ability to stay awake; and the Maintenance of Wakefulness Test (MWT), which objectively measures ability to stay awake. The Epworth Sleepiness Scale (ESS) is a self-rating sleepiness scale.
 
The long-term effectiveness of modafinil examined in a 40-week extension of these two investigations. After 40 weeks of Modafinil (Modalert 200) medication, approximately half of the 341 individuals reported near-normal ESS scores, indicating that they had moderate-to-severe narcolepsy. The Clinical Global Impression of Change, a typical illness-assessment technique used by doctors, showed that the participants’ disease severity had improved by more than 80%. There were no symptoms of drug tolerance.
 
During this long-term trial, data on quality-of-life evaluated in a separate investigation. The researchers employed a validated, self-administered health survey called the Medical Outcomes Study (Short Form 36), to which they added numerous narcolepsy-specific items. Throughout the 40-month period, all quality-of-life scores increased and remained stable. The most significant gains from a baseline of zero indicated in the table for individuals receiving 400 mg of modafinil. 
 

Sleep Apnea and EDS

 
EDS is a common sign of sleep apnea and sleeps apnea. The therapy of choice for obstructive sleep apnea, nasal continuous positive airway pressure (CPAP), can successfully remove EDS, as well as apnea episodes and associated cardiovascular effects. However, substantial EDS persists in certain instances for reasons that are still unknown. Because of their interference with sleep and the risk of cardiovascular events in this at-risk group, traditional CNS stimulants are not appropriate for treating EDS in sleep apnea.
 
Modafinil efficacy in treating residual EDS in sleep apnea has studied in two recent studies11, 12. Kingshott ET al11 studied 44 CPAP patients who given 400 mg of modafinil or a placebo in a randomized, double-blind, placebo-controlled crossover trial. They discovered a considerable improvement in alertness (as measured by the MWT). But no impact on drowsiness (as measured by the MSLT or the ESS), cognitive performance, or quality of life. The short sample size or the relative ability of the MWT, MSLT, and ESS to evaluate drowsiness may account for these moderate results. The researchers questioned whether the advantages of modafinil outweighed the risks. Waklert is a medicine that doctors recommend here and now.
 

Efficacy

 
Headache, nausea, dizziness, and sleeplessness were the most prevalent side effects of Modafinil (Modvigil). During the studies, 7% of participants stopped taking the medicine due to an adverse event. The most prevalent cause was a headache, while other factors included psychological symptoms including anxiety, agitation, irritability, and sadness. Patients on modafinil have committed suicide in the past.
 
Modafinil has linked to rashes, including one fatal instance of Stevens-Johnson syndrome. If a rash appears, the medicine should discontinued right once.
 
Modafinil probable medication interactions predicted to be comparable to Modafinil. Because modafinil slightly stimulates cytochrome P450 (CYP), it may lower medication concentrations metabolised by this enzyme, such as hormonal contraceptives, cyclosporin, carbamazepine, and midazolam. Modafinil inhibits CYP2C19 and may raise CYP2C19 substrate concentrations such as omeprazole, phenytoin, diazepam, propranolol, and clomipramine. With co-administered warfarin, more frequent INR monitoring may be necessary.
 
Women who use modafinil should use alternate contraception since it interacts with hormone contraceptives. Based on prior animal research with modafinil revealing prenatal effects and excretion in breast milk. Modafinil contraindicated in pregnancy and not suggested during lactation. 
 

Conclusion

Modafinil is a one-of-a-kind, generally safe CNS stimulant that can help individuals with EDS stay awake. It has fewer side effects and a reduced likelihood of tolerance than traditional CNS stimulants. 
Share121Tweet76Share30
AlexJames

AlexJames

Related Posts

Yellow Merino Wool Socks
Lifestyle

The Color Psychology of Yellow Merino Wool Socks

June 27, 2022

Have you ever wondered why our sun seems yellow? This is because it brightly emits light. And this is not just the literal meaning we are conversing about, it has an in-depth insight that you will understand once you...

Gold Rope Chains
Lifestyle

Are Gold Rope Chains Still Popular?

June 25, 2022

Trends come and go in a blink of an eye. Sometimes they’re hard to notice, forget follow them. Good old days when your dress or jewelry remained stylish for at least few years are gone for good. Nowadays, fashion...

Skateboarding Improve Child's Balance
Lifestyle

How Can Skateboarding Improve Child’s Balance And Coordination?

June 24, 2022

Skateboarding can be a great way to improve your balance and coordination if you are looking for a fun sport that you can do with your kids. That said, skateboarding is not the safest option for everyone, and it...

Girls Fashion
Fashion

Exclusive Girls Fashion

June 22, 2022

Reconsider while shopping restrictive young ladies style. How selective is this thing you find in the shopping center or the one you request on the Internet of a web-based kids store? Isn't elite frequently appended to some large name...

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

About Us

Hub Blogging

Hub Blogging

A Blogging Platfrom

Hub Blogging is an online blogging platform that is dedicated to providing knowledgeable articles to its audience in an exciting as well as informative tone. Keep Connected With Us!

Categories

  • Business (310)
  • Celebrity (3)
  • Cryptocurrency (15)
  • Digital Marketing (73)
  • DIY (3)
  • Education (65)
  • Entertainment (28)
  • Fashion (40)
  • Food (12)
  • Games (18)
  • General (70)
  • Health (137)
  • Home Improvement (79)
  • Lifestyle (134)
  • Social Media (21)
  • Technology (181)
  • Travel (37)
  • Uncategorized (112)
  • Website Review (2)

Popular

  • News Phxfeeds Com

    News Phxfeeds Com: Find Valid Info Here!

    367 shares
    Share 147 Tweet 92
  • TikTok Hot or Not Composite Images: Read to Know What It Is?

    326 shares
    Share 130 Tweet 82
  • Pikashow APK Download (Mod, Live IPL 2022) 75.0

    323 shares
    Share 129 Tweet 81
  • How to Register on Wpc2029 live? Read Details Here!

    321 shares
    Share 128 Tweet 80
  • An Effective Practice for Choosing Guest Post Agency

    315 shares
    Share 126 Tweet 79
  • Privacy Policy
  • Write For Us
  • About Us
  • Contact Us

© Hub Blogging Copyright 2022. All Rights Reserved.

No Result
View All Result
  • Lifestyle
  • Business
  • Entertainment
  • Celebrity
  • Digital Marketing
  • Technology
  • Travel
  • Crypto